David Lee Duewer, Ph.D.

National Institute of Standards and Technology

Chemical Sciences and Technology Laboratory

Gaithersburg, MD  20899-8390

Tel: 301-975-3935   

Email: david.duewer@nist.gov


Chemical metrologist with particular expertise in chemometrics, experimental design, exploratory data analysis, graphical communications, interlaboratory comparisons, measurement uncertainty, and quality assurance/control.

        Advocate for R&D at interfaces of chemistry, biology, measurement science, and statistics

        Experienced multi-disciplinary team builder and team leader

        Demonstrated ability to bring projects to timely completion




National Institute of Standards and Technology, Gaithersburg, MD

2002–Now Scientist V, Research Chemist

1991–2001 Scientist IV, Research Chemist

        Design and evaluation of interlaboratory studies

        Value, uncertainty, and traceability assignment of chemical and biological reference materials

        Comparability assessment of reference materials and measurement procedures

        Consulting data analyst, with focus on the development of graphical analysis and communication techniques


Monsanto Agricultural Company, St. Louis, MO

1986–1990 Senior Research Specialist, Herbicide Discovery
Champion of knowledge-driven methods for optimization of lead chemistries:
bioassays, chemical information systems, and structure/activity&property studies.

1982–1985 Research Specialist, Synthesis
Project leader responsible for acquisition and implementation of targeted synthesis
strategies: QSAR, experimental design, molecular modeling, and information access.

1979–1982 Senior Research Chemist, Process   
Member of chemical process computational support team: process control,
experimental design, kinetic and mass-balance models, and quality assurance.




1977–1979 Senior Fellow with G.D. Christian, University of Washington

1976–1977 Research Associate with H. Freiser, University of Arizona

1973–1976 Ph.D. Chemistry with B.R. Kowalski, University of Washington

1971–1973 NDEA Graduate Research with R.S. Juvet, Jr., Arizona State University

1967–1971 B.S. Cum Laude Chemistry, University of Washington



Professional Organizations


Membership Secretary, North American Chapter of the International Chemometrics Society

Chemometrics Liaison, The QSAR and Modelling Society





Manuscripts In Preparation


Duewer DL, Banks D.  Mixture-Model Probability Density Functions and the Robust Estimation of Location and Dispersion.


Duewer DL, Kline MC, Sharpless KE, Brown Thomas J.  NIST Micronutrients Measurement Quality Assurance Program: Fat-Soluble Vitamin Measurement Commutability of Lyophilized and Liquid-Frozen Serum Matrices.


Choquette SJ, O’Neal LE, Duewer DL, Hanssen LM, Zhu C.  Rare Earth Glass Reference Materials for Near Infrared Spectrometry: Certification of SRM 2065 Band Locations using multiple Fourier Transform Spectrometers.


Long SE, Welch MJ, Duewer DL.  Comparability Evaluation of Certified Reference Materials.


Stephen E. Long, Gregory Turk, David L. Duewer, Mary F. Burritt, John A. Butz, Richard R. Miller.  Comparability Evaluation of Reference Measurement Procedures.


Manuscripts In Review


Butler JM, Appleby JE, Liu D, Duewer DL.  Locus-specific brackets for reliable typing of Y-chromosome short tandem repeat markers.  Submitted to Electrophoresis.


Peer-Reviewed Publications

Choquette SJ, Duewer DL, Hanssen LM, Early EA.  SRM 2036 Near Infrared Reflection Wavelength Standard.  Applied Spec, in press.

Kline MC, Duewer DL, Redman JW, Butler JM.  Results from the NIST 2004 DNA Quantitation Study.  J Forensic Sci, in press.

Kline MC, Vallone PM, Redman, JW, Duewer DL, Calloway CD, Butler JM.  Mitchondrial DNA Typing Screens with Control Region and Coding Region SNPs.  J Forensic Sci, in press.

Travis JC, Acosta JC, Andor G, Bastie J, Blattner P, Chunnilall CJ, Crosson SC, Duewer DL, Early EA, Hengstberger F, Kim C-S, Liedquist L, Manoocheri F, Mercader F, Metzdorf J, Mito A, Monardh LAG, Nevask S, Nilsson M, Noël M, Rodriguez AC, Ruíz A, Schirmacher A, Smith MV, Valencia G, van Tonder N, Zwinkels J.  Intrinsic Wavelength Standard Absorption Bands in Holmium Oxide Solution for UV/visible Molecular Absorption Spectrophotometry.  J Physical and Chemical Reference Data, in press.

Duewer DL, Kline MC, Redman JW, Butler JM.  NIST Mixed Stain Study #3: Signal Intensity Balance in Commercial Short Tandem Repeat Multiplexes.  Anal Chem 2004;76:6928-6934.

Kline MC, Duewer DL, Redman JW, Butler JM.  NIST Mixed Stain Study #3: DNA Quantification Practice and its Influence on Short Tandem Repeat Multiplex Performance.  Anal Chem 2003;75(10):2463-2469.

Duewer DL, Choquette SJ, O’Neal LE, Zhu C, Filliben JJ.  Rare Earth Glass Reference Materials for Near Infrared Spectrometry: Sources of X-Axis Location Variability.  Anal Chim Acta 2003;490(1-2):85-98.

Margolis SA, Vangel M, Duewer DL.  Certification of SRM 970, Ascorbic Acid in Serum, and the Analysis of Associated Interlaboratory Bias in the Measurement Process.
Clin Chem 2003;49:463-469.

Choquette SJ, O’Neal LE, Duewer DL.  Rare-Earth Glass Reference Materials for Near Infrared Spectrometry: Absorption Band Temperature Dependencies.  Anal Chem 2003;75(4):961-966.

MacCrehan WA, Reardon MR, Duewer DL.  A Quantitative Comparison of Smokeless Powder Measurements.  J  Forensic Sci 2002;47(6):1283-1287.

Travis JC, Zwinkels JC, Mercader F, Ruiz A, Early EA, Smith MV, Noël M, Maley M, Kramer GW, Eckerle KL, Duewer DL.  A NORAMET Evaluation of Holmium Oxide Solution Reference Materials for Wavelength Calibration in Molecular Absorption Spectrometry.
Anal Chem 2002;74(14):3408-3415

Kline MC, Duewer DL, Redman JW, Butler JM. PCR Amplification of DNA from Aged Blood Stains: Quantitative Evaluation of the “Suitability for Purpose” of Four Filter-Papers as Archival Media.  Anal Chem 2002;74(8):1863-1869.

MacCrehan WA, Reardon MR, Duewer DL.  Associating gunpowder and residues from commercial ammunition using compositional analysis with the propellant to stabilizer ratio (P/S).  J Forensic Sci 2002;47(2):260-266.

Duewer DL, Kline MC, Redman JW, Newall PJ, Reeder DJ.  NIST Mixed Stain Studies #1 and #2:
Interlaboratory Comparison of DNA Quantification Practice and Short Tandem Repeat Multiplex Performance with Multiple-Source Samples. J Forensic Sci 2001;46(5):1199-1210.

MacCrehan WA, Patierno ER, Duewer DL, Reardon MR.  Investigating the effect of changing ammunition on the composition of organic additives in gunshot residue (OGSR).  J Forensic Sci 2001;46(1):57-62.

Choquette SJ, Travis JC, O’Neal LE, Zhu C, Duewer DL.  SRM® 2035: A rare earth oxide glass for the wavelength calibration of near infrared dispersive and Fourier transform spectrometers.  Spectroscopy 2001;16(4):14-19.

Thomas JB, Kline MC, Gill LM, Yen JH, Duewer DL, Sniegoski LT, Sharpless KS.  Preparation and value assignment of Standard Reference Material 968c Fat‑Soluble Vitamins, Carotenoids, and Cholesterol in Human Serum: Clin Chim Acta 2001;305:141-155.

Duewer DL, Richie KL, Reeder DJ.  RFLP band size standards: NIST Standard Reference Material® 2390.  J Forensic Sci 2000;45(5):1093-1105.

Duewer DL, Gary KT, Reeder DJ.  RFLP band size standards: Cell line K562 values from 1991 – 1997 proficiency studies.  J Forensic Sci 2000;45(5):1106-1118.

Duewer DL, Kline MC, Sharpless KE, Brown Thomas J.  NIST Micronutrients Measurement Quality Assurance Program: Characterizing the measurement community’s performance over time.  Anal Chem 2000;72(17):4163-4170.

Duewer DL, Kline MC, Sharpless KE, Brown Thomas J, Stacewicz-Sapuntzakis M, Sowell AL.  NIST Micronutrients Measurement Quality Assurance Program: Characterizing individual participant measurement performance over time.  Anal Chem 2000;72(15):3611-3619.

Duewer DL, Liu H‑K, Reeder DJ.  Graphical tools for RFLP DNA profiling.  Single-locus Charts.  J Forensic Sci  1999;44(5):969-977.

Gary KT, Duewer DL, Reeder DJ.  Graphical tools for RFLP DNA profiling. Laboratory Performance Charts.  J Forensic Sci  1999;44(5):978-982.

Duewer DL, Kline MC, Sharpless KE, Brown Thomas J, Gary KT, Sowell AL.  Micronutrients Measurement Quality Assurance Program: Helping participants use interlaboratory comparison exercise results to improve their long-term measurement performance.  Anal Chem 1999;71(9):1870-1878.

Thomas JB, Duewer DL, Kline MC, Sharpless KE.  The stability of retinol, a-tocopherol, trans-lycopene and trans-b-carotene in liquid-frozen and lyophilized serum.  Clin Chim Acta 1998;276(1):75-87.

Faber NM, Duewer DL, Choquette SJ, Green TL, Chesler SN.  Characterizing the uncertainty in near-infrared spectroscopic prediction of mixed-oxygenate concentrations in gasoline: sample-specific prediction intervals. Anal Chem 1998;70(14):2972-2982.  Correction: 1998;70(22);4877.

Duewer DL, Lalonde SA, Aubin RA, Fourney RM, Reeder DJ.  Interlaboratory comparison of autoradiographic DNA profiling measurements: precision and concordance.  J Forensic Sci 1998;43(3):465-471.

Chesler SN, Emery AP, Duewer DL.  Recovery of diesel fuel from soil by supercritical fluid extraction/gas chromatography.  J Chromatography A 1997;790(1-2):125-130.

Benzinger EA, Emerek EA, Grigsby NL, Duewer DL, Lovekamp ML, Deadman H, Thompson JL, Sallee PJ, Riech AK.  Products of partial digestion with HaeIII. Part 1. Characterization, casework experience and confirmation of the theory of three-, four- and five-banded RFLP pattern origins using partial digestion.  J Forensic Sci 1997;42(5):850-863.

Duewer DL, Benzinger EA.  Products of partial digestion with HaeIII. Part 2. Quantification.  J Forensic Sci 1997;42(5):864-872.

Kline MC, Duewer DL, Newall P, Redman JW, Reeder DJ, Richard M.  Interlaboratory evaluation of STR triplex CTT.  J Forensic Sci 1997;42(5):897-906.

Duewer DL, Currie LA, Reeder DJ, Leigh SD, Filiben JJ, Liu H‑K, Mudd JL.  Interlaboratory comparison of autoradiographic DNA profiling measurements. 4. Protocol effects  Anal Chem 1997;69(10):1882-1892.

Duewer DL, Brown Thomas J, Kline MC, MacCrehan WA, Schaffer R, Sharpless KE, May WE, Crowell JA.  NIST/NCI Micronutrients Measurement Quality Assurance Program: Measurement repeatabilities and reproducibilities for fat‑soluble vitamin‑related compounds in human sera.  Anal Chem 1997;69(7):1406-1413.

Choquette SJ, Chesler SN, Duewer DL, Wang S, O'Haver TC.  Identification and quantification of oxygenates in gasoline ampoules using Fourier‑transform near‑infrared and Fourier‑transform Raman spectroscopy.  Anal Chem 1996;68(20):3525‑3533.

Thomas JBR, Kline MC, Schiller SB, Ellerbe PM, Sniegoski LT, Duewer DL, Sharpless KE.  Certification of fat‑soluble vitamins, carotenoids, and cholesterol in human serum: Standard Reference Material 968b.  Fresenius J Anal Chem 1996;356(1):1‑9.

Margolis SA, Duewer DL.  Measurement of ascorbic acid in human plasma and serum: stability, intralaboratory repeatability, and interlaboratory reproducibility.  Clin Chem 1996;42(8):1257‑1262.

Kline MC, Redman JW, Reeder DJ, Duewer DL.  Intercomparison of DNA sizing ladders in electrophoretic separation matrices and their potential for accurate typing of the D1S80 locus.  Applied and Theoretical Electrophoresis 1996;6(1):33‑41.

Stolorow AM, Duewer DL, Reeder DJ, Buel E, Herrin G Jr.  Interlaboratory comparison of autoradiographic DNA profiling measurements. 3. Repeatability and reproducibility of RFLP band sizing, particularly bands of molecular size > 10k base pairs.  Anal Chem 1996;68(11):1941‑1947.

Sharpless KS, Duewer DL.  Population distributions and intralaboratory reproducibility for fat‑soluble vitamin‑related compounds in human serum.  Anal Chem 1995;67(23):4416‑4422.

Duewer DL, Currie LA, Reeder DJ, Leigh SD, Liu H‑K, Mudd JL.  Interlaboratory comparison of autoradiographic DNA profiling measurements. 2. Measurement uncertainty and its propagation.  Anal Chem 1995;67(7):1220‑1231.

Mudd JL, Baechtel FS, Duewer DL, Currie LA, Reeder DJ, Leigh SD, Liu H‑K.  Interlaboratory comparison of autoradiographic DNA profiling measurements. 1. Data and summary statistics.  Anal Chem 1994;66(20):3303‑3317.

Duewer DL, Clark RD.  Rank order analysis for robust multi‑response, multi‑block comparisons: evaluation of herbicide interactions.  J Chemometrics 1991;5(6):503‑521.

Duewer DL.  The Free‑Wilson paradigm redux: Significance of the Free‑Wilson coefficients, insignificance of coefficient “uncertainties”, and statistical sins.  J Chemometrics 1990:4;299‑321.

Worley JW, Morrell JA, Duewer DL, Peterfreund LA.  Alternate indexes of variation for the analysis of experimental data.  Anal Chem 1984;56(3):462‑466.

Duewer DL, Christian GD.  A modular recording titrimeter for use with luminescent endpoint detection.  J Chem Biochem Environ Instrument 1979;9(4):373‑393.

Duewer DL, Kowalski BR, Clayton KS, Roby JR.  Elucidating the structure of some clinical data.  Comput Biomed Res 1978;11(6):567‑580.

Saxberg BEH, Duewer DL, Booker JL, Kowalski BR.  Pattern recognition and blind assay techniques applied to forensic separation of whiskey.  Anal Chim Acta 1978;103:201‑212.

Duewer DL, Freiser H.  Relating molecular structure to metal chelate stability and reagent selectivity; abstract factor analysis of the chelate formation equilibrium for some diaminetetracarboxylic acids.  Anal Chem 1977;49(13):1940‑1949.

Duewer DL, Kowalski BR, Fasching JL.  Improving the reliability of factor analysis of chemical data by utilizing the measured analytical uncertainty.  Anal Chem 1976;48:2002‑2010.

Duewer DL, Kowalski BR, Schatzki TF.  Source identification of oil spills by pattern recognition analysis of natural elemental composition.  Anal Chem 1975;47(9):1573‑1583.

Duewer DL, Kowalski BR.  Forensic data analysis by pattern recognition. Categorization of white bond papers by elemental composition.  Anal Chem 1975;47(3):526‑530.

Li KP, Duewer DL, Juvet RS Jr.  Kinetics of chromatographic processes with application to the steepest descent approximation method.  Anal Chem 1974;46(9):1209‑1214.


Non-Peer Reviewed or Courtesy-Author Publications

Travis JC, Duewer DL, Salit ML.  Intrinsic Standards for UV-VIS Spectrophotometry, Amer Lab 2004:36(16);34-40.

Duewer DL.  A Robust Approach for the Determination of CCQM Key Comparison Reference Values and Uncertainties, Working document CCQM 04-15, BIPM (2004).

Duewer DL, Parris RM, White E, May WE, Elbaum H.  An Approach To The Metrologically Sound Traceable Assessment Of The Chemical Purity Of Organic Reference Materials.  NIST Special Publication 1012, NIST, Gaithersburg (MD), pp. 53 (2004).

Travis, JC, Duewer DL.  Holmium Oxide Solution as a Prototype Intrinsic Standard in Molecular Absorption Spectrophotometry, in Proceedings of SPIE Volume 4826 (Fourth Oxford Conference on Spectroscopy).  Springsteen A and Pointer M, Eds.  Pp. 113-122 (2003).

Travis JC, Smith MV, Duewer DL.  NISTIR 6961, Report of the Results of SIM.QM-P6: UV/Visible Spectrophotometry Wavelength Standard Interlaboratory Comparison.  NIST, Gaithersburg (MD), pp.30 (2003).

Choquette SJ, Travis JC, Zhu C, Duewer DL.  Wavenumber Standards for Near Infrared Spectrometry, in Handbook of Vibrational Spectroscopy.  Chalmers JM and Griffiths PR, Eds.  John Wiley & Sons, Ltd, Volume 1, pp. 899-905 (2002).

Verkouteren JR, Duewer DL.  NISTIR 5951, Guide for quality control on the qualitative and quantitative analysis of bulk asbestos samples: version 1. NIST, Gaithersburg(MD, pp. 19 (1997).

Clark RD, Parlow JJ, Brannigan LH, Schnur DM, Duewer DL.  Applications of scaled rank‑sum statistics in herbicide QSAR.  In: Hansch C, Fujita T, editors.  Classical and Three‑Dimensional QSAR in Agrochemistry, ACS Symposium Series No. 606.  Washington: American Chemical Society; pp 264-281 (1995).

Anderson DK, Deu[sic]wer DL, Sikorski JA.  Syntheses of new 2-Hydroxythiazol-5-yl and
3-Hydroxy-1,2,4-triazol-ylphosphonic acids as potential cyclic spatial mimics of glyphosate.
J Heterocyclic Chem 1995:32(3);893-8.

Duewer DL, Chesler SN, Schönberger E, MacCrehan WA.  Implementation and characterization of a robotic protocol for the extraction of fat‑soluble vitamins in human serum.  Inter Symp Laboratory Automation Robotics 1992 Proceedings. Hopkinton (MA): Zymark. Pp. 727-741 (1993).

Brannigan LH, Duewer DL.  Experimental design in the development of biologically active compounds.  Proc 8th Euro Symp QSAR, Sorrento Italy, Sep 1990.  Amsterdam: Elsevier. (1991).

Mulligan TJ, Lappi L, Kieser R, Yamada SB, Duewer DL.  Salmon stock identification based on elemental composition of vertebrae.  Canadian J Fish Aquatic Sci 1983:40(2);215-29.

Knudson EJ, Duewer DL, Christian GD, Larson TV.  Application of factor analysis to the study of rain chemistry in the Puget Sound region.  In: Kowalski BR, editor.  Chemometrics: Theory and Application, ACS Symposium Series No. 52.  American Chemical Society, pp 80-93 (1977).

Harper AM, Duewer DL, Kowalski BR, Fasching JL.  ARTHUR and experimental data analysis: the heuristic use of a polyalgorithm.  In: Kowalski BR, editor.  Chemometrics: Theory and Application, ACS Symposium Series No. 52.  American Chemical Society, pp 14-52 (1977).