Dr. Michael D. Coble

Education

B.S., Biology   Appalachian State University (Boone, NC) 1991.

M.F.S., Forensic Science   George Washington University (Washington, D.C.) 1997.

Ph.D., Genetics   George Washington University (Washington, D.C.) 2004.

Experience

Director of Research     Armed Forces DNA Identification Laboratory: April 2006 - present

Research Biologist        Biochemical Science Division, National Institute of Standards and Technology: December 2005 - April 2006

Post Doc                           NRC Postdoctoral Fellow, Biotechnology Division, National Institute of Standards and Technology: 2003-2005

Research Technologist/Ph.D. Candidate - The Armed Forces DNA Identification Laboratory (Rockville, MD): August 1996 – December 2003.

Membership and Committees

American Society of Human Genetics

Mid-Atlantic Association of Forensic Scientists (Membership Committee)

Publications

Coble, M.D., Vallone, P.M., Just, R.S., Diegoli, T.M., Smith, B.C., Parsons, T.J. (2006) Effective strategies for forensic analysis in the mitochondrial DNA coding region. Int. J. Legal. Med. 120:27-32. [Supplementary Data].

 

Niederstätter, H., Coble, M.D., Grubwieser, P., Parsons, T.J., Parson, W. (2006) Characterization of mtDNA SNP typing and mixture ratio assessment with simultaneous real-time PCR quantification of both allelic states. Int. J. Legal Med. 120:18-23.

 

Yong, R.Y.Y., Gan, L.S.H., Coble, M.D., Yap, E.P.H. (2006) Allele frequencies of six miniSTR loci of three ethnic populations in Singapore. Forensic Sci. Int., in press.

 

Butler, J.M., Coble, M.D., Decker, A.E., Duewer, D.L., Hill, C.R., Kline, M.C., Redman, J.W., Vallone, P.M. (2005) Setting standards and developing technology to aid the human identity testing community. Progress in Forensic Genetics 11, in press.

 

Coble, M.D., Hill, C.R., Vallone, P.M., Butler, J.M. (2005) Characterization and performance of new miniSTR loci for typing degraded samples. Progress in Forensic Genetics 11, in press.

 

Coble, M.D. and Butler, J.M. (2005) Characterization of new miniSTR loci to aid analysis of degraded DNA. J. Forensic Sci. 50: 43-53.

 

Just, R.S., Irwin, J.A., O'Callaghan, J.E., Saunier, J.L., Coble, M.D., Vallone, P.M., Butler, J.M., Barritt, S.M., Parsons, T.J. (2004) Toward increased utility of mtDNA in forensic identifications. Forensic Sci. Int. 146S: S147-S149.

 

Ph.D. Dissertation – “The Identification of Single Nucleotide Polymorphisms in the Entire Mitochondrial Genome to Increase the Forensic Discrimination of Common HV1/HV2 Types in the Caucasian Population.”,  January, 2004, 206 pp. 

 

Coble, M.D., Just, R.S., O'Callaghan, J.E., Letmanyi, I.H., Peterson, C.T., Irwin, J.A., Parsons, T.J. (2004) “Single nucleotide polymorphisms over the entire mtDNA genome that increase the power of forensic testing in Caucasians.” Int. J. Legal Med., 118(3): 137-146.

 

Vallone, P.M., Just, R.S., Coble, M.D., Butler, J.M., Parsons, T.J. (2004) A multiplex allele-specific primer extension assay for forensically informative SNPs distributed throughout the mitochondrial genome. Int. J. Legal Med., 118(3): 147-157.

 

Edson, S.M., Ross, J.R., Coble, M.D., Parsons, T.J., and Barritt, S.M. (2004) “Naming the Dead — Confronting the Realities of Rapid Identification of Degraded Skeletal Remains.” Forensic Science Reviews 16(1): 64-89.

 

Levin, B.C., Holland, K.A., Hancock, D.A., Coble, M., Parsons, T.J., Kienker, L.J., Williams, D.W., Jones, M.P., and Richie, K.L. (2003) “Comparison of the complete mtDNA genome sequences of human cell lines - HL-60 and GMIO742A - from individuals with pro-myelocytic leukemia and leber hereditary optic neuropathy, respectively, and the inclusion of HL-60 in the NIST human mitochondrial DNA standard reference material - SRM 2392-I.” Mitochondrion 2: 387-400.

 

Parsons, T.J. and Coble, M.D. (2001) "Increasing the Forensic Discrimination of Mitochondrial DNA Testing Through Analysis of the Entire Mitochondrial DNA Genome.”  Croatian Medical Journal 42(3): 304-309.

 

Steighner, R.J., Tully, L.A., Karjala, J.D., Coble, M.D., and Holland, M.M. (1999) “Comparative Identity and Homogeneity Testing of the mtDNA HV1 Region Using Denaturing Gradient Gel Electrophoresis.”  Journal of Forensic Science 44(6): 1186 – 1198.

Presentations

For a list of presentations made Dec 2003 - April 2006 see, http://www.cstl.nist.gov/biotech/strbase/NISTpub.htm#Presentations